Antihypertension Activity of Gynura procumbens (Lour.) Merr. Extract On Blood Pressure And Monoxide Nitrogen Levels In Male White Rats

Hypertension is closely related to vasodilation disorders because of the
decreased availability of nitrogen monoxide (NO). The purpose of this
study was to determine the decrease in blood pressure and nitrogen
monoxide (NO) levels in rats after administration of Gynura procumbens
leaves extract. The results showed that the administration of Gynura
procumbens leaves extracts significantly reduced blood pressure and
increased NO levels. From the results of Duncan's test, it was found that the
dose of 300mg / Kg BW showed a better effect on increasing NO levels (p
<0.05). From the results of the study, it can be concluded that the ethanol
extract of Gynura procumbens leaves has an antihypertensive activity that
can reduce blood pressure and increase the NO level.